CARIS SCIENTIFIC ADVANCES

2021 Caris ASCO Posters

24 Posters Accepted at ASCO 2021

Caris Life Sciences scientists and collaborators from the Precision Oncology Alliance™  (POA) presented new findings to advance cancer care and guide treatment decisions at the 2021 American Society of Clinical Oncology (ASCO) Virtual Annual Meeting, June 4 to 8, 2021. The data presented answers relevant clinical questions about some of the most prevalent and deadly cancers in the world, from common tumors like non-small cell lung cancer to less common cancers like sarcoma.

Three gastrointestinal presentations earned Merit Awards from the congress, recognizing fellows and oncology trainees whose research is addressed in high-quality abstracts. The scope of data across various cancer types demonstrate the significance of the POA, as well as the Caris’ portfolio of artificial intelligence-powered offerings, in furthering the advancement of individualized therapies for patients with cancer. You can view all of the abstracts below by clicking on their respective titles.

The entire library of Caris publications can be found here: Caris Publications

Genomic evaluation of tumor mutational burden-high (TMB-H) versus TMB-low (TMB-L) metastatic breast cancer to reveal unique mutational features.

Institutions: Duke University; Georgetown University/MedStar; Levine Cancer Institute/Atrium
Health Cancer Institute; USC Norris Comprehensive Cancer Center; Vanderbilt University

Molecular characterization of the Ras-MAPK pathway in metastatic breast cancer.

Institutions: USC Norris Comprehensive Cancer Center

Identification and prognostic impact of PBRM1 mutations in biliary tract cancers: Results of a comprehensive molecular profiling study.

Institutions: Medical University of Innsbruck, Austria; IRCCS Ospedale Policlinico San Martino,
Genoa, Italy; Oncologic Day Hospital, Hospital of Bressanone (SABES-ASDAA), Bressanone-Brixen,
Italy; West Virginia University; West Cancer Center; Karmanos Cancer Institute; Georgetown
University/MedStar; Fox Chase Cancer Center; USC Norris Comprehensive Cancer Center; Brown
University; UT Southwestern Medical Center

High CXCR4 expression in pancreatic ductal adenocarcinoma as characterized by an inflammatory tumor phenotype with potential implications for an immunotherapeutic approach.

Institutions: Medical University of Innsbruck, Austria; USC Norris Comprehensive Cancer Center;
Oncologic Day Hospital, Hospital of Bressanone (SABES-ASDAA), Bressanone-Brixen, Italy; West
Virginia University Cancer Institute; West Cancer Center; Karmanos Cancer Institute; Georgetown
University; Fox Chase Cancer Center

A comprehensive landscape of BRCA1 vs BRCA2 associated molecular alterations and survival outcome across 35 cancer types.

Institutions: IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Emory University; Medical
University of Innsbruck, Austria; West Virginia University Cancer Institute; Brown University;
Georgetown University/MedStar; Duke Cancer Institute; University of Minnesota School of
Medicine; Karmanos Cancer Institute; USC Norris Comprehensive Cancer Center; University of
Cincinnati; Levine Cancer Institute

Increased neutrophil infiltration and lower prevalence of tumor mutation burden and microsatellite instability are hallmarks of RAS mutant colorectal cancers.

Institutions: University of Minnesota; Levine Cancer Institute; UT Southwestern Medical Center;
Sarah Cannon Research Institute, United Kingdom; Emory University; Karmanos Cancer Institute;
West Virginia University Cancer Institute; Arizona Cancer Center; University of Kansas Medical
Center; USC Norris Comprehensive Cancer Center; Brown University

Comprehensive characterization of neurotransmitters and neuronal signaling (NT) pathway alterations in colorectal cancer (CRC).

Institutions: USC Norris Comprehensive Cancer Center; Stanford University; West Virginia
University; Washington University School of Medicine; Levine Cancer Institute; Medical University
of Innsbruck, Austria; Lawrence J. Ellison Institute for Transformative Medicine; Karmanos Cancer
Institute; Georgetown University/MedStar

Globo H expression in metastatic colorectal cancer (CRC).

Institutions: USC Norris Comprehensive Cancer Center; West Virginia University Cancer Institute;
Georgetown University/MedStar; University of Minnesota School of Medicine; Fox Chase Cancer
Center; University of South Alabama; Cleveland Clinic

Association of ATM mutations in metastatic prostate cancer with differential genomic alteration profiles from homologous recombination deficient and proficient tumors.

Institutions: University of Minnesota; Brown University; Tulane Cancer Center; University of
Cincinnati Medical Center; University of Miami; Fox Chase Cancer Center; Karmanos Cancer
Institute

Association of high gene expression levels of ARF6 with the immune microenvironment and prediction of poor outcomes.

Institutions: USC Norris Comprehensive Cancer Center; Chiba Cancer Center, Chiba, Japan;
Stanford University Medical Center; Karmanos Cancer Institute; Cleveland Clinic; University of
South Alabama; Georgetown University/MedStar; Fox Chase Cancer Center; St Jude Heritage
Medical Group; University of Miami; University of Minnesota

HER2 in uterine serous carcinoma: Testing platforms and implications for targeted therapy.

Institutions: University of Minnesota; University of South Alabama; Washington University School
of Medicine in St. Louis; Massachusetts General Hospital; University of Pennsylvania School of
Medicine; Rutgers Cancer Institute of New Jersey; University of Texas MD Anderson Cancer Center;
Duke Cancer Institute; Wayne State University School of Medicine; Karmanos Cancer Institute;
University of Cincinnati Cancer Institute; University of Alabama at Birmingham

Immune-response markers and actual response to immune-oncology therapy in uterine serous carcinoma.

Institutions: University of South Alabama; Fox Chase Cancer Center; Levine Cancer Institute at
Atrium Health; University of Cincinnati; AdventHealth Cancer Institute; Washington University
School of Medicine

Exploring molecular profiles of uterine carcinosarcoma with alterations in the chromatin remodeling pathway.

Institutions: University of South Alabama; University of Minnesota; Magee-Women’s Hospital of
UPMC; Levine Cancer Institute at Atrium Health; University of Cincinnati; AdventHealth Cancer
Institute; Washington University School of Medicine in St. Louis

Association of the presence of estrogen and progesterone receptors in uterine carcinosarcoma with improved survival and increased immunogenicity.

Institutions: University of South Alabama; University of Minnesota; Washington University School
of Medicine; Levine Cancer Institute at Atrium Health; University of Cincinnati; AdventHealth
Cancer Institute

Molecular determinants of response to immune-oncology therapy in uterine carcinosarcoma.

Institutions: University of South Alabama; University of Minnesota; Levine Cancer Institute at
Atrium Health; University of Cincinnati; AdventHealth Cancer Institute; Wayne State University/
Karmanos Cancer Center; Washington University School of Medicine in St. Louis

Exploring molecular profiles and survival in hormone receptor-positive uterine serous carcinoma.

Institutions: Fox Chase Cancer Center; University of South Alabama; Levine Cancer Center

Deciphering the molecular landscape and the tumor microenvironment of perivascular epitheloid cell neoplasma (PEComa).

Institutions: Comprehensive Cancer Center Innsbruck; Huntsman Cancer Institute; Rutgers
Cancer Institute; Fox Chase Cancer Center; University of Minnesota; John Wayne Cancer Institute;
University of Miami

Multiomic analysis to reveal distinct molecular profiles of uterine and non-uterine leiomyosarcoma.

Institutions: Rutgers Cancer Institute; Brown University; Columbia University; Comprehensive
Cancer Center Innsbruck; Fox Chase Cancer Center; Emory University; Translational Genomics
Research Institute; Duke University; Huntsman Cancer Institute; Weill Cornell Medical College;
University of Arizona; University of Minnesota; University of South Alabama; Emory University;
University of Miami

Large scale multiomic analysis suggests mechanisms of resistance to immunotherapy in leiomyosarcoma.

Institutions: Columbia University; Rutgers Cancer Institute; Brown University; Comprehensive
Cancer Center Innsbruck; Georgetown University/MedStar; Fox Chase Cancer Center; Emory
University; Translational Genomics Research Institute; Duke University; Huntsman Cancer Institute;
Weill Cornell Medical College; University of Arizona; University of Minnesota; University of South
Alabama; University of Miami

Genomic and immunologic characterization of large-cell neuroendocrine carcinoma of the lung.

Institutions: Georgetown University/MedStar; Barbara Ann Karmanos Cancer Institute; Penn State
Cancer Institute; USC Norris Comprehensive Cancer Center; University of Miami; Fox Chase Cancer
Center; Emory University Winship Cancer Institute; Translational Genomics Research Institute,
UPMC Hillman Cancer Center

Real-world multiomic characterization of small cell lung cancer subtypes to reveal differential expression of clinically relevant biomarkers.

Institutions: Huntsman Cancer Institute; National Cancer Institute; Comprehensive Cancer Center
Innsbruck; Karmanos Cancer Institute; University of Minnesota; University of Miami; Montefiore;
Fox Chase Cancer Center; Georgetown University/MedStar; Emory University

STK11/TP53 co-mutated non-small cell lung cancer (NSCLC) to display a unique tumor microenvironment (TME) and metabolic profile.

Institutions: National Cancer Institute; Dana-Farber Cancer Institute; Georgetown University/
MedStar; Fox Chase Cancer Center; Memorial Cancer Institute; University of Miami; USC Norris
Comprehensive Cancer Center; Georgetown University/MedStar; Barbara Ann Karmanos Cancer
Institute

Incidence of ERBB gene fusions (EGFR, ERBB2, ERBB4) across tumor types.

Institutions: University of Colorado; Rain Therapeutics; University of Minnesota; Fox Chase Cancer
Center; Hoag; University of California San Diego; Georgetown University/MedStar; University of
California Irvine; New England Cancer Specialists; Brown University

Analysis of immune checkpoint blockade biomarkers in elderly patients using large-scale cancer genomics data.

Institutions: Johns Hopkins University/Hospital; University of Miami; Georgetown University/
MedStar; Cedars-Sinai Medical Center; Fox Chase Cancer Center; USC Norris Comprehensive
Cancer Center